Fig. 5: Exemplary realization of self-stabilization in focal adhesions.
From: Generic self-stabilization mechanism for biomolecular adhesions under load
a Talin binds with its globular head to integrins and with its rod to actin filaments. The first domain to unfold under force is the R3 domain with two vinculin-binding sites. b State diagram for the talin-vinculin model. Averaged steady-state simulation results for different linking ratios λ = λ+/λ−. See Supplementary Notes I for parametrization. c Vinculin recruitment produces self-stabilization. d The relative motion of the top plane, modeling actin fibers, is reduced through vinculin-based self-stabilization.
