Fig. 2: MC simulation for light delivery and heat management.
From: AI-enabled, implantable, multichannel wireless telemetry for photodynamic therapy
a Overview of the integrated MC simulator. The simulation platform processes parameters from a user and performs analysis of thermal dissipation, light propagation, and energy absorption. One can determine the best PDT regimen to be the most effective in activating a photosensitizer. b Three-dimensional and cross-sectional view of a tumor-tissue model (left). Light scattering and heatmap at a wavelength of 406 nm and 652 nm, respectively for activation of Foscan (middle). Plots of variation in temperatures as a function of time during each mode of operation; constant and 25 Hz with 10 ms on (right). The best PDT regimen for activation of Hypericin c and Foscan d. Five criteria include 1. degree of light penetration, 2. rate of energy absorbance, 3. level of uniformity of energy absorbance into a tumor cell, 4. the time required for delivery of targeted light energy, and 5. range of temperature variation.
