Fig. 2: Gene set enrichment and interaction networks analysis identify functional pathways important for wild-type SARS-CoV-2 and variants of concern infection. | Nature Communications

Fig. 2: Gene set enrichment and interaction networks analysis identify functional pathways important for wild-type SARS-CoV-2 and variants of concern infection.

From: Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2

Fig. 2

a Gene set enrichment analysis (GSEA) was performed by analysis of the directed scores of all genes from the WT-SARS-CoV-2 and VOCs screens combined (infection), and for the uninfected cell viability screen (viability). Results from the infection screens were filtered to get significantly enriched pathways with false discovery rate (FDR) of less than 0.01. The enrichment of each of these pathways in each screen is represented as bubbles colored by Normalized enrichment score (NES) and sized by significance levels. b Protein–protein interaction network for top 200 enriched hits from all strain screens combined based on STRING analysis. Edge thickness represents interaction score. Nodes are colored by selected REACTOME pathways and sized according to log10 transformed screen enrichment score. Source data are provided as a Source Data file.

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