Table 1 Affected SNPs in the UC-associated signalling network, their target genes and interactions^a.

SNP	Target gene name	Regulatory annotation of the SNP
rs11041476	LSP1	TFBS in an enhancer, miRNA-TS in the first intron
	TNNI2	TFBS in an enhancer
rs11168249	RAPGEF3	TFBS in an enhancer
	HDAC7	TFBS in an enhancer, miRNA-TS in the first intron
rs11676348	ARPC2	TFBS in an enhancer
	CXCR1
	CXCR2
	SLC11A1
	CTDSP1
rs12254167	CCNY	TFBS in an enhancer
rs1598859	NFKB1	TFBS in an enhancer
	CISD2	TFBS in an enhancer
rs17085007	RPL21	TFBS in an enhancer
	GTF3A	TFBS in an enhancer
rs1801274	FCGR2A	miRNA-TS in an exon
rs3774937	NFKB1	miRNA-TS in an intron
rs477515	*HLA-DQA2*	TFBS in an enhancer
	*HLA-DQB1*
	*HLA-DQB2*
	*C4A*
	*HSPA1B*
	*HLA-DPA1*
	*AGER*
	*NOTCH4*
rs543104	CCDC82	TFBS in an enhancer
rs559928	RPS6KA4	TFBS in an enhancer
rs6087990	DNMT3B	TFBS in a promoter
rs7404095	*PRKCB*	miRNA-TS in a intron
rs907611	LSP1	TFBS in a promoter
rs913678	*SNAI1*	TFBS in an enhancer
	*CEBPB*
	*PTPN1*
rs943072	*VEGFA*	TFBS in an enhancer
	*XPO5*
	*POLH*

^aDetails of each interaction are provided in Supplementary Table 1. Cluster-driving SNPs affecting the regulation of a high number of proteins directly or through their first neighbours are shown in bold.

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