Fig. 4: Drug treatments increase the correlations between the activity of pathways.

A Scatter plots of the activity scores of p38 and p53 reporters in the A375 signalome cell line before and at multiple time points after treatment with 122 active drugs. Each dot represents a different drug. Pearson’s r is depicted for each of the time points. B Pearson correlation coefficients were calculated for each pair of pathways in the A375 signalome cell line before and at different time points after treatment with 122 active drugs. Each datapoint represents a correlation value for one given pair of pathways over all 122 active drugs. The correlation between the activity score of p38 and p53 pathways is marked by a red circle. C–H Locally weighted smoothing (Lowess) regression of all reporters in each of the two signaling states is shown for six representative drug treatments, each associated with different drug targets. While three of the drugs drive the p53-signaling state (C–E), the other three drugs drive the p38 signaling state (F–H). The bold (red and blue) lines and the gray sleeves represent mean values and + /− SEM respectively. Source data are provided with this paper.