Fig. 2: Structural comparison of active VIP2R, VIP1R, and PAC1R. | Nature Communications

Fig. 2: Structural comparison of active VIP2R, VIP1R, and PAC1R.

From: A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

Fig. 2: Structural comparison of active VIP2R, VIP1R, and PAC1R.The alternative text for this image may have been generated using AI.

a Superimposition of PACAP27–VIP2R, PACAP27–VIP1R (PDB code: 6VN7)13 and PACAP38–PAC1R (PDB codes: 6M1I, 6LPB, and 6P9Y)14,15,16 reveals a high structural similarity. Receptor ECD and G protein are omitted for clarity. b Surface representations of peptide-binding pockets among VIP2R, VIP1R, and PAC1R. The bound peptides are shown as sticks ribbon and sticks.

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