Fig. 10: WAKE in IPCs modulates male-male courtship behaviour in Drosophila through endocrine network effects on Or67d neurons. | Nature Communications

Fig. 10: WAKE in IPCs modulates male-male courtship behaviour in Drosophila through endocrine network effects on Or67d neurons.

From: WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour

Fig. 10

WAKE in IPCs of the adult brain affects Rdl to modulate Ilp2 homoeostasis. WAKE in adult male IPCs modulates JH biosynthesis from the CA via IIS stabilization. It may reduce 20E synthesis via the continuous JH signalling, thereby reducing ecdysone signalling. Our results indicate that reduced ecdysone signalling results in modulating the neural architecture of Or67d neurons (nerve fibres indicated in green) and leads to reduced responsiveness to the male-specific cVA pheromone (blue lines), prompting significant male-male courtship behaviour.

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