Fig. 2: MAFs and effect sizes for the lead GWAS SNVs and indels.

a Distribution of MAFs for the lead GWAS-significant (Wald-test, p < 5.00 × 10–8) primary and conditional hits. A MAF threshold of 0.01 was used in the GWAS and, consequently, no GWAS hits had a MAF below 0.01. b Effect sizes from the GWAS, in relation to MAF for the primary and conditional GWAS hits. All effect estimates are reported as absolute values.