Fig. 2: Survey of metabolome in TBI patients and controls.
From: Serum metabolome associated with severity of acute traumatic brain injury
a Polar metabolite (MC) and lipid (LC) clusters across the study groups. Mean of orthopedic and internal medicine controls was used as a reference, and the significant differences between the groups and the reference are marked. b Heatmap of the TBI-reference patient groups and the top 23 metabolites as selected by the overlap of the random forest feature selection and the Welch t test significant feature evaluation. Unknown polar metabolites and lipids are marked as Xmet and Xlip, respectively c Individual discriminatory performance for the top 23 metabolites. Each metabolite was used in a logistic regression model as predictor, with group affinity as response. The performance was averaged on 100 model runs of 70–30% data splits. Data are presented as mean values with the individual run performances as points (n = 100) and aggregated 95% CI.
