Fig. 6: Biosafety assessment of PIDA. | Nature Communications

Fig. 6: Biosafety assessment of PIDA.

From: Precisely translating computed tomography diagnosis accuracy into therapeutic intervention by a carbon-iodine conjugated polymer

Fig. 6

a Hemolysis assay and images (insert) of RBCs incubated with different samples (n = 3 biologically independent samples). The percentage of RBC lysis was <5% for PIDA. b Viability of 4T1, NIH 3T3, and HEK 293 T cells pretreated with a series of doses of PIDA (n = 4 biologically independent samples). c. Body weights of rats received the treatment and control rats (n = 3 biologically independent samples). d, e CT images of PIDA in muscle at different time after injection. f Plots of CT values of PIDA and iohexol ([I]: 4 mg mL−1, 200 μL) injected in rats as a function time. g H&E staining of main organs after being injected with PIDA. The experiment was repeated 3 times independently with similar results. Scale bars: 0.5 mm. All data are presented as Mean ± SD. Source data are provided as a Source Data file.

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