Fig. 2: Detailed study on the reaction media and amine sources. | Nature Communications

Fig. 2: Detailed study on the reaction media and amine sources.

From: Efficient access to general α-tertiary amines via water-accelerated organocatalytic multicomponent allylation

Fig. 2

a Effect of reaction medium. b Detailed study on the amine source. aConditions: Reactions were performed with ketone (0.2 mmol), amine source (1.2 equiv.), allylboronic acid pinacol ester 3a (1.5 equiv.) and set of catalysts (5.0 mol%) with medium (2.0 mL: 10 L/mol (1a or 10h)) at 60 °C for 24 h. bYields were determined by 1H NMR analysis using 1,3,5-trimethoxybenzene as internal standard. cn.d. = not detected. Bn = benzyl; t-Bu = tert-butyl; Bz = benzoyl; Et = ethyl; Me = methyl; Ph = phenyl.

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