Fig. 5: Substrate scope of allylation reaction (continued from Fig. 4). | Nature Communications

Fig. 5: Substrate scope of allylation reaction (continued from Fig. 4).

From: Efficient access to general α-tertiary amines via water-accelerated organocatalytic multicomponent allylation

Fig. 5

a 2,2,2-Trifluoromethyl ketone. b Aldehyde. c Bioactive molecule. aConditions: Reactions were performed with ketone or aldehyde (0.2 mmol), benzhydrazide 2a (1.2 equiv.), allylboronic acid pinacol ester 3a (1.5–2.5 equiv.), and a set of catalysts (5.0–10 mol%) with water (2.0 mL: 10 L/mol (ketone or aldehyde)) and PhMe (5.0 equiv.) at 60 °C for 24–48 h. bYields were determined after chromatographic purification. Ar = aryl group; Bz = benzoyl; Me = methyl; Ph = phenyl.

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