Fig. 2: Optimisation of coupling reaction conditions.
From: Copper-catalysed asymmetric reductive cross-coupling of prochiral alkenes
All reactions were carried out in a 0.5 mmol scale using 1a (1.5 equiv.) and 2a (1.0 equiv.) under a N2 atmosphere at 40 °C, unless otherwise noted. Yields of 3a are isolated and diastereomeric ratio of product 3a was determined via 1H NMR analysis of the unpurified mixtures and was high (>98:2) in all cases. B2pin2 = Bis(pinacolato)diboron.
