Fig. 2: Initial substrate assessment of desymmetric B–H bond insertion reaction. | Nature Communications

Fig. 2: Initial substrate assessment of desymmetric B–H bond insertion reaction.

From: Construction of boron-stereogenic compounds via enantioselective Cu-catalyzed desymmetric B–H bond insertion reaction

Fig. 2: Initial substrate assessment of desymmetric B–H bond insertion reaction.

Conditions: a 2-arylpyridine-borane (1) (0.1 mmol, 1.0 equiv), diazo compound (2) (0.1 mmol, 1.0 equiv), Cu(MeCN)4PF6 (5 mol%), ligand L (6 mol%), solvent (1 mL) at 0 °C for 9 h. b Isolated yield. c Determined by chiral HPLC. d Diazo compound 2aa instead of 2a. e Diazo compound 2ab instead of 2a.

Back to article page