Fig. 2: Structure of the ovine b0,+AT–rBAT heterodimer. | Nature Communications

Fig. 2: Structure of the ovine b0,+AT–rBAT heterodimer.

From: Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria

Fig. 2: Structure of the ovine b0,+AT–rBAT heterodimer.

a Detailed depiction of the b0,+AT–rBAT subcomplex, derived from 3D multi-body refinement (see Methods). Note that the complex is re-oriented from Fig. 1e to the membrane normal. CHOL, cholesterol; POPC, palmitoyl oleoyl phosphatidyl choline; TMD; transmembrane domain; ED, ectodomain; NAG, N-acetylglucosamine. b The rBAT ectodomain. The Ca2+ ion, N-linked glycans, and individual subdomains are labeled. c b0,+AT complexed with rBAT TM1′. Lipids and individual TMs are labeled. CH, C-terminal helix; NH, N-terminal helix.

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