Fig. 6: Phylogeny of Kdm5c/d and increased expression of Kdm5c in females vs. males in therian mammals.
From: Activation of Xist by an evolutionarily conserved function of KDM5C demethylase
a Inferred phylogeny of Kdm5c/d during mammalian evolution6,7,73. Top row, Kdm5c transcript per million (TPM) levels in four tissues, as indicated, in females vs. males for seven eutherian species, one metatherian (marsupial) species (opossum), and two prototherian (monotreme) species (platypus and echidna). Bottom row, average TPM of all X-linked genes in females vs. males in the same tissues analyzed for Kdm5c expression. Platypus and echidna TPM averages are from Chromosome (Chr) 6, where KDM5C maps in those species73. The dark gray horizontal line in all plots represents the mean of all tissues. Light gray lines connect corresponding tissue types between males and females. b Distribution of female:male expression of genes across the therian X chromosome or monotreme Chr 6. Each dot is the log2 fold change of a gene’s expression in females vs males and was calculated from the average of that gene’s TPM in the brain, heart, kidney, and liver; human plot includes expression from the brain, heart, and kidney. See Supplementary Data 1–12 for sequencing data from each species.
