Table 1 Characteristics of patients with Kawasaki disease (KD) and MIS-C analyzed in this study.

From: An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease

Demographic and clinical parameters

KD

MIS-C

p

 

CAA− (n = 10)

CAA+ (n = 10)

MIS-C (n = 10)

 

Age, yrsa

2.2 (1.8–3.7)

1.8 (1.2–3.5)

8.8 (5.7–11.1)

0.0002

Illness dayb

6 (5–7)

6 (5–7)

4 (3–4)

NS

Male, n (%)

6 (60)

8 (80)

6 (60)

NS

Ethnicity, n (%)

    

Asian

1 (10)

1 (10)

0

NS

African American

1 (10)

1 (10)

2 (20)

 

White

3 (30)

2 (20)

1 (10)

 

Hispanic

4 (40)

3 (30)

6 (60)

 

>2 races

2 (20)

5 (50)

1 (10)

 

Zmax

1.0 (0.7–1.2)

3.1 (2.7–3.3)

1.9 (1.5–2.2)

0.0002

LVEF, median (IQR, range)

67 (65–68, 56–76)

70 (62–75, 56–79)

58 (55–62, 31–65)

0.006

Lab data

    

WBC, 103/µL

12.6 (11.6–18.3)

15.8 (13.0–18.5)

11.1 (5.5–11.7)

0.01

ANC, /µL

9159 (6904–106830

11319 (8896–12539)

8172 (4437–10071)

NS

ALC, /µL

2576 (1739–3658)

2924 (2379–5075)

939 (803–1019)

0.0002

AEC, /µL

184 (104–529)

378 (322–588)

122 (0–231)

0.04

ZHgb

−1.4 (−2.3–0.1)

−1.5 (−1.8 to 0.6)

−2.2 (−2.7 to 0.7)

NS

PLT, 103/mm3

330 (278–396)

363 (338–396)

177 (106–228)

0.002

ESR, mm/h

55 (30–64)

68 (58–76)

44 (36–59)

NS

CRP, mg/dL

6.1 (4.8–12.2)

5.9 (4.0–8.0)

21 (19.6–23.8)

0.01

BNP, pg/mL

ND

ND

33 (19.7–23.6)

NA

Ferritin, ng/mL

ND

ND

323 (223–960)

NA

Troponin, ng/mL

ND

ND

0.02 (0.01–0.13)

NA

D-dimer, µg/mL

ND

ND

1.94 (1.24–2.40)

NA

SARS-CoV-2 testing

    

PCR positive

ND

ND

1 (10)

NA

IgG positivec

ND

ND

10 (100)

NA

Treatment, n (%)

    

IVIG×1

10 (100)

10 (100)

8 (80)

NS

IVIG×2

0

1 (10)

1 (10)

NS

Infliximab

4 (40)

10 (100)

3 (30)

0.003

Anakinra

0

1 (10)

1 (10)

NS

Cyclosporine

0

1 (10)

0

NS

Steroids

0

0

7 (70)

0.0001

  1. Table displays the demographic, clinical and laboratory parameters collected on the KD and patients with MISC-C enrolled into the study. Zmax Maximum Z score (internal diameter normalized for body surface area) for the right and left anterior descending coronary arteries. Laboratory data are pre-treatment. Troponin was measured in nine patients with MIS-C. D-dimer was measured in eight patients with MIS-C. p-values were calculated by Kruskal–Wallis test for continuous variables among three groups and Chi-test for categorical variables.
  2. LVEF left ventricular ejection fraction, WBC white blood cell count, PLT platelets, AEC absolute eosinophil count, ANC absolute neutrophil count, ALC absolute lymphocyte count, CRP C-reactive protein, ESR erythrocyte sedimentation rate, BNP brain natriuretic peptide, ZHgb hemoglobin concentration normalized for age, NS not significant, NA not applicable, ND not done.
  3. aMedian (Interquartile range (IQR) unless specified.
  4. bIllness Day 1 = first day of fever.
  5. cSARS-CoV-2 nucleocapsid IgG positive n = 9 and SARS-CoV-2 peptide array n = 1.
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