Fig. 1: TM-catalyzed hydroarylation of alkynes with (hetero)arenes.
From: Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds
a Three types of hydroarylations of alkynes and (hetero)arenes: electron-rich arenes (type I), electron-deficient arenes (type II), and general arenes with unactivated C(sp2)−H bonds (type III). b Stability of metallacycles and reported various metallacycle-involved hydroarylations: γ-C−H bond-activation-involved hydroarylation (widely explored); δ-C−H bond-activation-involved hydroarylation (rarely explored); β-C−H bond-activation-involved hydroarylation (elusive challenge); c β-C−H bond-involved hydroarylation via 7-membered metallacycles (this work). T.M. = transition metal. Het = heterocycle, D = electron-donating group. W = electron-withdrawing group. DG = directing group. PO = phosphine oxide ligand.
