Fig. 3: Microfluidic models for molecular diagnostics.

Theoretical device design for back-to-back analysis of CTCs and circulating proteins and DNA from whole blood. Whole blood is perfused through a series of microchambers and microchannels that leverage several microscale-based separation techniques to isolate multiple components such as immune cells, CTCs, ctDNA, proteins, and exosomes. Next, cells and analytes are either retrieved or analyzed in situ.