Fig. 5: Immunohistochemical staining of three diagnostic biomarkers in tissues and their clinical significance. | Nature Communications

Fig. 5: Immunohistochemical staining of three diagnostic biomarkers in tissues and their clinical significance.

From: Noninvasive urinary protein signatures associated with colorectal cancer diagnosis and metastasis

Fig. 5: Immunohistochemical staining of three diagnostic biomarkers in tissues and their clinical significance.The alternative text for this image may have been generated using AI.

a Representative immunohistochemistry images and score distribution of CORO1C, RAD23B, and ARPC5 expression in paracarcinoma normal tissues (PN) and CRC tumors (tumor). The median and quartile values in each group of individuals are shown as thick red dash lines and thin black dotted lines, respectively. Scale bar: 50 μm. The statistical analysis was performed by two-sided Mann–Whitney rank test. b The balloon plot for the clinical significance of CORO1C, RAD23B, and ARPC5 in colon adenocarcinoma patients with distinct staining intensities. The number in the circle is the sample size, and the percentage next to the circle is the corresponding percentage. Chi-square test was used for calculating the two-sided P values. Neg negative, Weak weak expression, Str. strong expression. The source data are provided in Source Data.

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