Fig. 3: Staggering of the N- and C-terminal lobes in the RML prion fibril. | Nature Communications

Fig. 3: Staggering of the N- and C-terminal lobes in the RML prion fibril.

From: 2.7 Å cryo-EM structure of ex vivo RML prion fibrils

Fig. 3

Top, cryo-EM density (MAP) and solvent-excluded surface (MODEL) of three rungs, with indicated side chains that connect to form the inter-lobe contacts. The F174 and H176 residues are better visible in the MAP and MODEL views, respectively. Bottom, magnified view of the staggered interactions (hydrophobic contacts) shown with transparent surface, main chain as ribbon and selected interacting residues as sticks.

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