Fig. 6: Network analysis of Nkx2.5 targets reveals distinct nodes that coordinate GRNs governing regenerative pathways.
From: Activation of Nkx2.5 transcriptional program is required for adult myocardial repair
A, B Network analyses of DamID targets in set A (turquoise border) and set B (magenta border). Color represents the fold change in injured compared to uninjured wild-type CMs (WT7 vs WT0) (A) and injured compared to uninjured nkx2.5−/− CMs (MT7 vs MT0) (B). Red is upregulated and blue is downregulated, as shown in the key. Mitochondrial metabolism modules are labeled in purple, proteolysis modules are labeled in orange, and cell cycles modules are labeled in green.
