Fig. 7: Pore conformation.
From: Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC
a Superposition of the narrow neck region of the hourglass-shaped pore of the rebuilt Ca2+-free apo (PDB: 5OYG) and the 1PBC/Ca2+-bound structures viewed from the top. Asterisk indicates the pore axis. b Molecular surface of the neck region viewed from the top. Selected residues lining the volume are shown. c Pore radius along the z-axis relative to the position of Ile 641 (gate). The locations of constrictions are indicated. Asterisk indicates the location of the 1PBC binding site. Dashed line denotes the ionic radius of a Cl− ion.
