Fig. 3: Two possible orientations of dyclonine in the portal site.
From: Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine
Pore domain in TRPV3Dyc with dyclonine in the head towards the pore (blue, a, b) or tail towards the pore (green, c, d) orientations, viewed parallel to the membrane (a, c) or extracellularly (b, d). The F666 side chains and dyclonine molecules are shown in sticks. Only two of four TRPV3 subunits are shown in (a) and (c), with the front and back subunits omitted for clarity.
