Fig. 5: Conformational changes that accompany dyclonine binding.
From: Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine
Superposition of the pore domains in TRPV3Dyc (blue) and apo-state TRPV3 (PDB ID: 7MIN; orange) viewed parallel to the membrane (a) or extracellularly (b). The F666 side chains and dyclonine molecules are shown in sticks. Only two of four TRPV3 subunits are shown in (a), with the front and back subunits omitted for clarity. Blue arrows indicate flipping of the F666 side chain, movement of P-loop extracellularly and of dyclonine towards the pore center upon binding in the transmembrane portals.
