Fig. 6: TRPV3Dyc pore and its radius in comparison with the closed and open states. | Nature Communications

Fig. 6: TRPV3Dyc pore and its radius in comparison with the closed and open states.

From: Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine

Fig. 6

a Pore-forming domain in TRPV3Dyc with the residues contributing to pore lining in the dyclonine-bound (TRPV3Dyc), closed (TRPV3Closed) and open (TRPV3Open) states shown as sticks. Only two of four subunits are shown, with the front and back subunits omitted for clarity. The pore profile is shown as a space-filling model (green). The region that undergoes α-to-π transition in S6 is highlighted in pink. b Pore radius for TRPV3Dyc (blue), TRPV3Closed (orange, PDB ID: 7MIN) and TRPV3Open (green, PDB ID: 7MIO) calculated using HOLE. The vertical dashed line denotes the radius of a water molecule, 1.4 Å.

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