Fig. 3: Cell cycle analysis in mouse and human cellular models.
From: Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning
A The transcriptional phases and the cell cycle phases were connected based on marker genes. Z-scores are only intended for comparison purposes, the changes in the expression across the cycle are, in general, highly significant. B The UMAP embeddings for mESCs, ductal cells, and human fibroblasts with the cell cycle directionality identified by DeepCycle (black arrows). The cells are associated with different colors depending on the cell cycle phase they belong to, light blue for cells in G1, red in S, and dark green in G2/M. C RNA counts per cell as a function of the transcriptional phase show doubling trends followed by a sudden drop that identifies mitosis.
