Table 3 Treatment-related adverse events.
No. (%) | ||||||
|---|---|---|---|---|---|---|
All Grade | Grade 3 or 4 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
Elevated AST | 34 (74.0) | 8 (17.4) | 10 (21.7) | 16 (34.8) | 8 (17.4) | 0 |
Elevated ALT | 30 (65.2) | 8 (17.4) | 5 (10.9) | 17 (37.0) | 8 (17.4) | 0 |
Leukopenia | 30 (65.2) | 6 (13.0) | 6 (13.0) | 18 (39.1) | 4 (8.7) | 2 (4.3) |
Hand-foot syndrome | 25 (54.3) | 3 (6.5) | 14 (30.4) | 8 (17.4) | 3 (6.5) | 0 |
Neutropenia | 24 (52.2) | 14 (30.4) | 4 (8.9) | 6 (13.0) | 9 (19.6) | 5 (10.9) |
Alopecia | 19 (41.3) | 0 | 10 (21.7) | 9 (19.6) | 0 | 0 |
Fatigue | 18 (39.1) | 0 | 10 (21.7) | 8 (17.4) | 0 | 0 |
Thrombocytopenia | 16 (34.8) | 9 (19.6) | 3 (6.5) | 4 (8.7) | 7 (15.2) | 2 (4.3) |
Rash | 16 (34.8) | 2 (4.3) | 4 (8.7) | 10 (21.7) | 2 (4.3) | 0 |
Canker sore | 11 (23.9) | 0 | 5 (10.9) | 6 (13.0) | 0 | 0 |
Anorexia | 10 (21.7) | 0 | 5 (10.9) | 5 (10.9) | 0 | 0 |
Gingivitis | 8 (17.4) | 0 | 7 (15.2) | 1 (2.2) | 0 | 0 |
Lose weight | 8 (17.4) | 0 | 6 (13.0) | 2 (4.3) | 0 | 0 |
Pneumonia | 8 (17.4) | 1 (2.2) | 1 (2.2) | 6 (13.0) | 1 (2.2) | 0 |
Voice hoarse | 8 (17.4) | 0 | 8 (17.4) | 0 | 0 | 0 |
Diarrhea | 7 (15.2) | 0 | 5 (10.9) | 2 (4.3) | 0 | 0 |
Hypertension | 7 (15.2) | 0 | 2 (4.3) | 5 (10.9) | 0 | 0 |
Hypothyroidism | 7 (15.2) | 1 (2.2) | 3 (6.5) | 3 (6.5) | 1 (2.2) | 0 |
Proteinuria | 7 (15.2) | 0 | 5 (10.9) | 2 (4.3) | 0 | 0 |
Capillary hemangioma | 7 (15.2) | 0 | 6 (13.0) | 1 (2.2) | 0 | 0 |
Insomnia | 6 (13.0) | 0 | 2 (4.3) | 4 (8.7) | 0 | 0 |
Fever | 6 (13.0) | 1 (2.2) | 3 (6.5) | 2 (4.3) | 1 (2.2) | 0 |
Elevated bilirubin | 6 (13.0) | 3 (6.5) | 1 (2.2) | 2 (4.3) | 3 (6.5) | 0 |
Pain | 6 (13.0) | 1 (2.2) | 0 | 5 (10.9) | 1 (2.2) | 0 |
Elevated CK-MB | 5 (10.9) | 0 | 4 (8.7) | 1 (2.2) | 0 | 0 |
Hypoalbuminema | 5 (10.9) | 0 | 1 (2.2) | 4 (8.7) | 0 | 0 |
Hemoglobin reduction | 5 (10.9) | 2 (4.3) | 2 (4.3) | 1 (2.2) | 2 (4.3) | 0 |
Constipation | 4 (8.7) | 0 | 3 (6.5) | 1 (2.2) | 0 | 0 |
Hemoglobinuria | 4 (8.7) | 0 | 4 (8.7) | 0 | 0 | 0 |
Headache | 4 (8.7) | 0 | 3 (6.5) | 1 (2.2) | 0 | 0 |
Hydropericardium | 3 (6.5) | 1 (2.2) | 2 (4.3) | 0 | 1 (2.2) | 0 |
Infusion reaction | 3 (6.5) | 0 | 0 | 3 (6.5) | 0 | 0 |
Stomachache | 3 (6.5) | 0 | 2 (4.3) | 1 (2.2) | 0 | 0 |
Hyperthyroidism | 2 (4.3) | 0 | 0 | 2 (4.3) | 0 | 0 |
Blurred vision | 2 (4.3) | 0 | 1 (2.2) | 1 (2.2) | 0 | 0 |
