Fig. 5: Predominant Hallmark signatures that vary along the PCP continuum. | Nature Communications

Fig. 5: Predominant Hallmark signatures that vary along the PCP continuum.

From: Gene expression signatures of individual ductal carcinoma in situ lesions identify processes and biomarkers associated with progression towards invasive ductal carcinoma

Fig. 5

a Single-sample Gene Set Enrichment Analysis (ssGSEA) score for the Epithelial to Mesenchymal transition Hallmark signature. Samples are ordered according to the principal curve projection. b Heatmap showing expression of key proliferation genes (CCND1 – Top2A) and key EMT (CDH2-SNAI2) genes. Samples were ordered according to the principal curve projection. Relative expression is provided as log2 counts per million (CPM) minus the mean log2 CPM for each gene.

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