Table 1 Pharmacokinetic parameters of compound YK-2-69 in SD ratsa.

From: Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer

Compd.

Admin.

Cmax (ng/mL)

AUC0-∞ (h*ng/mL)

MRT0-∞ (h)

Tmax (min)

t1/2 (h)

CL (mL/h/kg)

F (%)

YK-2-69

IV

974

1503

3.5

2

3

669

–

PO

674

8384

8.9

240

5

1198

56

  1. Dose: p.o. at 10 mg/kg. Dose: i.v. at 1 mg/kg. Source data are provided as a Source Data file.
  2. Cmax maximum concentration, AUC area under the plasma concentration-time curve, MRT mean residence time, t1/2 half-life, CL clearance, F oral bioavailability.
  3. aValues are the average of three runs.
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