Fig. 8: Proposed models of how bulky glycoproteins respond to membrane curvature.
From: Membrane curvature regulates the spatial distribution of bulky glycoproteins
A On vertical nanostructures, MUC1 shows a preference for negatively-curved and flat membranes over positively-curved ones. B MUC1 prefers IRSp53-induced negatively-curved membranes rather than FBP17-induced positive curvature. C Molecular repulsions and the free energy of bulky glycoproteins are minimized as the cell membrane accommodates a negative curvature. D Steric and electrostatic repulsions and the free energy are increased when the cell membrane adopts a positive curvature.
