Fig. 6: Subcutaneous adipose ADIPINT expression and PC activity correlate with each other and are increased in obesity.
From: The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase
Analyses of a ADIPINT expression, b PC protein and c PC activity in subcutaneous adipose tissue of 10 women without obesity (lean) and 9 women with obesity (Cohort 2). d ADIPINT expression plotted against PC activity in the same patient. A body mass index (BMI) of ≥30 kg/m2 was used to distinguish individuals with obesity and BMI of <25 kg/m2 for control. PC activity was normalized to PC protein expression from the same adipose tissue sample. e ADIPINT expression in subcutaneous adipose tissue of 20 women without obesity and 20 women with obesity (Cohort 3). A BMI of ≥ 30 kg/m2 was used to distinguish individuals with obesity and BMI of <30 kg/m2 for control. ADIPINT expression from both Cohort 2 and 3 plotted against f total percentage fat mass, g fat cell volume, h plasma triglycerdies i homeostasis model assessment of insulin resistance (HOMA-IR) and adipose tissue insulin resistance index (ADIPO-IR). Linear regression assessed significance in correlation analyses. A one-tailed t-test assessed significance between individuals with and without obesity. Each data point represents an individual patient, error bars represent SEM. Source data are provided as a Source Data file.
