Fig. 1: Schematic illustration of peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche.
From: Peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche
a Illustration of the pathological process of pre-metastatic niche (PMN) formation. The primary tumor produces pro-metastatic factors, such as tumor-derived secreted factors (TDSF), to induce fibroblast activation in metastatic destination organs. The tumor-educated activated fibroblasts serve to construct a metastasis-supportive host stroma, including extracellular matrix (ECM) deposition and reconstruction, angiogenesis and vascular leakage, as well as myeloid-derived suppressor cells (MDSC) recruitment. b After FR17 subcutaneous administration, the in-situ assembled peptide nano-blanket in PMN stromal microenvironment impedes fibroblasts activation so as to retard stromal and vessel pro-metastatic reconstruction, inhibiting MDSC recruitment and metastatic cascades.
