Fig. 2: Substrate scope of the enantioselective alkylative cross-coupling of unactivated C–O bond.
From: Enantioselective alkylative cross-coupling of unactivated aromatic C–O electrophiles
Unless otherwise stated, the reactions were carried out by using C–O electrophiles (0.2 mmol), R′–MgBr (3.0 equiv.), Ni(cod)2 (10 mol%), L1 (20 mol%) in PhMe (0.1 M) at 60 °C for 24 h; aThe reaction was conducted at 80 °C; bR′–MgCl (3.0 equiv.) were used and reactions were conducted at 60 °C for 36 h; cEthyl magnesium bromide (Et–MgBr) (3.0 equiv.) was used; dCyclo-hexyl magnesium bromide (C6H11–MgBr) (3.0 equiv.) was used; ePhenylmagnesium chloride (Ph–MgCl) (3.0 equiv.) was used.
