Fig. 4: Gram-scale synthesis and derivation experiments. | Nature Communications

Fig. 4: Gram-scale synthesis and derivation experiments.

From: Enantioselective alkylative cross-coupling of unactivated aromatic C–O electrophiles

Fig. 4: Gram-scale synthesis and derivation experiments.

a Gram scale synthesis. b Derivations based on the sp2 C–H bond modification. c Derivations based on benzylic sp3 C–H bond modification. d Derivations based on aromatic C–OH bond modification. MOMCl chloromethyl methyl ether, DMF dimethylformamide, DMCC dimethylcarbamyl chloride, DMAP 4-dimethylaminopyridine, AIBN azobisisobutyronitrile, NBS N-bromosuccinimide, dppe 1,2-bis(diphenylphosphino)ethane.

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