Fig. 5: Rational expansion for the synthesis of deuterated axially chiral compounds of type A.
From: Enantioselective alkylative cross-coupling of unactivated aromatic C–O electrophiles
The reactions were carried out by using C–O electrophiles (1.0 equiv.), CD3–MgI (4.0 equiv.), Ni(cod)2 (10 mol%), L1 (20 mol%), MgBr2 (5.0 equiv.) in PhMe (0.1 M) at 80 °C for 24 h. Isolated yields were reported, ee was determined by using chiral HPLC.
