Fig. 4: Asymptomatic and mildly symptomatic children do not display different antibody responses.
From: SARS-CoV-2 accessory proteins reveal distinct serological signatures in children
Pediatric and adult samples were stratified according to the symptom score of the patients (asymptomatic “asympto” (pediatric COVID-19 n = 98, adults COVID-19 n = 10) versus symptomatic “symptom” (pediatric COVID-19 n = 156, adults COVID n = 52)), data from Figs. 1 and 2 were analyzed according to “asympto” and “sympto”. a Antibodies against the SARS-CoV-2 structural proteins S1, S2, S2′, N, E, and M by LIPS. Significant p values for asympto pediatrics versus asympto adults are S1 p = 0.0005, S2′ p = 0.0221, E p = 0.0071. Significant p values for sympto pediatrics versus sympto adults are S1 p < 0.0001, S2′ p = 0.0016, M p < 0.0001, E p < 0.0001. b Antibodies against SARS-CoV-2 NSP1 (in ORF1ab), and all other ORFs (ORF3a, ORF3d, ORF6, ORF7a, ORF7b, ORF8, and ORF10). Significant p values for asympto pediatrics versus asympto adults are ORF3d p < 0.0001, ORF7a p = 0.0358, ORF7b p = 0.0208. Significant p values for sympto pediatrics versus sympto adults are NSP1 p = 0.0001, ORF3d p < 0.0001, ORF6 p < 0.0001, ORF7a p < 0.0001, ORF7b p < 0.0001, ORF8 p < 0.0001, ORF10 p < 0.0001. Two-sided P values were calculated using the Mann–Whitney U test. * shows statistical significance between COVID-19 patients versus negative controls. *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0,0001. All data represents individual time point LIPS responses and mean ± stdev.
