Fig. 2: In vitro peptide release from remote loaded microspheres.
From: Efficient aqueous remote loading of peptides in poly(lactic-co-glycolic acid)
Cumulative in vitro drug release from remote-loaded PLGA microspheres for (a) leuprolide compared to Lupron Depot®, NS (b) octreotide compared to Sandostatin LAR®, two-parent octreotide groups were significantly different on day 1, 3, 7, 14, 21, 28, 56, and two total octreotide groups were significantly different on day 1, 3, 7, 14, 21, 42, 56, (p < 0.05). c vasopressin, and d salmon calcitonin. Data are presented as mean values ± SEM (n = 3 independent experiments), except for leuprolide remote loading group (Not Sterile 180 mg/mL) in panel a was presented as mean with two individual data (n = 2 independent experiments). All remote-loaded microspheres were from non-sterile blank PLGA and from 180 mg/mL peptide solution. Parent and total peptide release listed for specific peptides not fully stable in the polymer. Sandostatin LAR® control data from Beig et al.23.
