Table 1 Peptide-PLGA binding parameters by isothermal titration calorimetry at 37 °C in DMSO and efficiency of remote loading in PLGA 75/25 microspheres by absorption at 1 day at 37 °C.
From: Efficient aqueous remote loading of peptides in poly(lactic-co-glycolic acid)
Peptide | Association constant (mM−1) | Stoichiometry | Δ H (kJ/mol) | −TΔ S (kJ/molK) | Δ G (kJ/mol) | Loading (%) | Encapsulation efficiency (%) | |
|---|---|---|---|---|---|---|---|---|
Leuprolide | 22.6 ± 7.0 | 1.04 ± 0.01 | −5.54 ± 0.01 | −20.3 ± 1.1 | −25.8 ± 0.9 | 9.64 ± 0.01 | 96.4 ± 0.02 | |
Octreotide | 14.3 ± 1.5 | 0.62 ± 0.04 | −39.9 ± 2.7 | 15.2 ± 2.9 | −24.7 ± 0.3 | 8.49 ± 0.01 | 84.9 ± 0.1 | |
Vasopressin | 56.4 ± 4.7 | 1.09 ± 0.01 | −3.35 ± 0.33 | −24.9 ± 0.2 | −28.2 ± 0.3 | 8.00 ± 0.32 | 86.6 ± 3.4 | |
Salmon Calcitonin | 30.5 ± 4.0 | 0.34 ± 0.03 | −49.2 ± 3.9 | 22.5 ± 4.0 | −26.6 ± 0.2 | 8.17 ± 0.66 | 80.8 ± 5.0 | |
