Fig. 1: Selected naturally occurring chiral cyclopentenones, the known substrates in asymmetric Nazarov cyclization for construction of chiral cyclopentenone.

a Representative examples of naturally occurring cyclopentenones with a 5-hydroxy-bearing quaternary stereocenter. b Divinyl ketones: dominant substrates in asymmetric Nazarov cyclization. c Vinyl diketoesters: developed by the group of Tius. d Dienyl diketones: developed by the group of Frontier.