Fig. 2: Effects of PRATA on hypertension of different causes and sympathetic output.
From: Perirenal adipose afferent nerves sustain pathological high blood pressure in rats
a, b Weekly measurement of arterial mean BP post PRATA in SHRs using radiotelemetry in the daytime (a) and at night (b), n = 6 per group; Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ANOVA, Bonferroni post-hoc test, two-sided. c, d Weekly measurement of tail arterial BP post PRATA in SHR (c) and WKY rats (d), n = 7 per group; Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ANOVA, Bonferroni post-hoc test, two-sided. e, f weekly measurement of tail arterial BP post PRATA in high fat diet (HFD) induced hypertensive rats (e) and high salt diet (HSD) induced hypertensive rats (f), n = 7 per group; Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ANOVA, Bonferroni post-hoc test, two-sided. g, h Changes of renal sympathetic and cervical vagal nerve discharge (g) and quantification (h), n = 6 per group; Data are mean ± SEM. *P < 0.05, ***P < 0.001, ****P < 0.0001. ANOVA, Bonferroni post-hoc test, two-sided.
