Fig. 4: Comparisons of EA integration with frequency-based analysis in clinical/environmental datasets.
From: Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli
Frequency analysis and EA integration ranks (EA-KS and EA-sum) of the mutated genes in ciprofloxacin resistant (a, b) and colistin resistant (c, d) clinical/environmental strains. Known drivers (orange) and genes with mutations that contribute to fitness in the presence of antibiotic (cyan) are highlighted. Median rank of ciprofloxacin resistance driver gene ranks (e) and colistin resistance driver gene ranks (f) in down-sampling analysis wherein random subsets of the samples were chosen for analysis by EA-KS (red/circles), EA-sum (green/triangles) or frequency (blue/squares). Interquartile range is displayed as error bars from 10 independent random draws at the indicated sample size. Source data are provided as a Source Data file.
