Fig. 3: The distribution of SBS18/SBS36 tumor mutational signature, reconstruction error and somatic single nucleotide variant (SNV) count by the five tumor classification categories. | Nature Communications

Fig. 3: The distribution of SBS18/SBS36 tumor mutational signature, reconstruction error and somatic single nucleotide variant (SNV) count by the five tumor classification categories.

From: Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures

Fig. 3

Distribution of a SBS18/SBS36 tumor mutational signature, b tumor mutational signature reconstruction error, and c adjusted somatic SNV count across 5649 CRCs in the training set, validation set, and test set, grouped by germline pathogenic variant status (tumor classifications). The red horizontal line in each figure indicates the cut-offs that were determined based on the training set and validation set tumors. All boxes correspond to the 25th and 75th percentiles and the whiskers represent 1.5× the inter-quartile range (IQR) extending from the boxes. Lines at the middle of each box show the median. Individual observations are shown beyond the whiskers. Source data are provided as a Source Data file.

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