Fig. 4: Allosteric modulation of D1R by PAM.
From: Ligand recognition and biased agonism of the D1 dopamine receptor
a Surface representation of D1R. EM densities for LY3154207 and cholesterol are shown. b Detailed interactions between LY3154207, cholesterol, and the receptor. Residues involved in binding are shown as sticks. c–e Structural comparison of the dopamine-LY3154207-bound D1R with D1R bound to dopamine alone.
