Fig. 5: GATA2 governing nucleosome states switching from Veh to DHT-treated conditions.
From: Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model
a Open chromatin was detected by ATAC-seq for GATA2 binding sites associated with nucleosome states switching in Veh and DHT-treated conditions respectively. b Overlapping between GATA2-associated nucleosome state switching genes and AR-regulated differentially expressed genes in DHT-treated condition. Differentially expressed genes were detected with p value <0.05 and | log2(Fold Change)| > 1. c KEGG pathway analyses showing the top pathways in S4-RAS1 and S3-RAS2 respectively. d The location of the GATA2 motif between ChIP-exo borders relative to the density map of MNase-seq reads for positioned nucleosomes. e The prediction of regulatory features and modules by i-cisTarget illustrating several top enriched TF motifs in unique GATA2-associated nucleosome state switching genes. f SOX9 is the most enriched co-binding TF on WNT signaling genes identified by a publicly available database that collected all ChIP-seq of TFs from ENCODE and ChEA.
