Fig. 6: Proposed model for the mechanism of glycosylation-mediated antigen escape.
From: Antigen glycosylation regulates efficacy of CAR T cells targeting CD19
(left) Normal SPPL3 function results in standard glycosylation of CD19. (Middle) Loss of SPPL3 results in increased and altered glycosylation, disrupting the CAR binding epitope. (Right) Increased SPPL3 results initially in decreased glycosylation followed by degradation of CD19, preventing surface presenation.
