Fig. 5: Leave one region out (LoRo) analysis underscores the importance of specific brain regions. | Nature Communications

Fig. 5: Leave one region out (LoRo) analysis underscores the importance of specific brain regions.

From: Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder

Fig. 5: Leave one region out (LoRo) analysis underscores the importance of specific brain regions.The alt text for this image may have been generated using AI.

a Brain visualizations and violin plots depicting the contribution of each ROI in the differential correlation after the specific region was removed (LoRo). Brain visualizations represent the −log10(FDR) of the comparative analysis between ROIs after LoRo analysis (One-sided Wilcoxon’s rank sum test). Violins represent the Z-score (Y-axis) of differential correlation after the specific region (X-axis) was removed. **** corresponds to a significant lower Z-score compared with other regions (p < 0.001; One-sided Wilcoxon’s rank sum test). Dots represent the mean Z-score for the specific Brodmann area. Lines represent the standard deviation (SD). N = 415 genes from independent analysis. Exact P-value: BA17 p < 2e−16, BA20_37 p < 2e−16, BA38 p = 6.8e−05, BA39_40 p < 2e−16, BA4_6 p < 2e−16. b Bubblechart with −log10(FDR) and Odds Ratio from Fisher’s Exact test representing enrichment between developmental groups and genes differentially expressed in each region. X-axis shows abbreviations for each region. Y-axis represents each developmental cluster identified.

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