Fig. 4: Somatic mutations in genes encoding DNA damage, immune-associated, and mitogen-activated protein kinase (MAPK) pathways correlate with ICB response.
From: Recurrent somatic mutations as predictors of immunotherapy response
a Volcano plot of fishHook-nominated pathways with log2 odds ratio for ICB response (x-axis) and significance of association with ICB response (y-axis). Statistical significance was tested using a two-sided Wald’s test of coefficients with multiple-hypothesis correction (FDR < 0.2). b fishHook-nominated pathways that overlap top-ranked genes from a genome-wide CRISPR screen for immunotherapy resistance (FDR-corrected one-sided hypergeometric test). c–d Volcano plots of odds ratio (responders/non-responders) and nominal p-values for genes in two of the fishHook-nominated pathways: Scavenging by Class A Receptors (c) and MAP2K and MAPK Activation (d). Red outlines indicate genes that were also found in the CRISPR screen. Indicated p-values are from the fishHook model using the observed mutation rate for each gene.
