Fig. 6: Conformational change of MTA1 upon p2 binding.
From: Structural basis for MTA1c-mediated DNA N6-adenine methylation
a Structural comparison of the SAM-binding pocket of MTA1 in the MTA1-MTA9 (left panel), MTA1-p2 (central panel) and MTA1-p1-p2 (right panel) complexes. Each MTA1 structure shows SAM-binding pocket in the SAM-free state. For comparison, a SAM molecule was modelled in the SAM-binding pocket of MTA1. b The SAM-binding pocket presents significantly different conformations in the structures of MTA1-MTA9 (left panel), MTA1-p2 (central panel) and MTA1-p1-p2 (right panel) complexes. Each MTA1 structure shows SAM-binding pocket in the SAM-free state. For comparison, a SAM molecule was modelled in the SAM-binding pocket of MTA1. c Superposition of the SAM-binding pocket within MTA1 in the MTA1-MTA9 complex (MTA1 in gray) with that in the SAM-bound MTA1-p2 (SAM in green, MTA1 in violet and p2 in marine) complex. d Structural comparison between MTA1 (violet) and MTA9 (orange). e MTA9 shows a potential SAM-binding pocket, a SAM molecule (green) was modelled in the potential SAM-binding pocket. f Superposition of the potential SAM-binding pocket of MTA9 (orange) with the SAM-binding pocket of MTA1 in the SAM-bound MTA1-p2 (SAM in green, MTA1 in violet) complex.
