Fig. 6: Trajectories of hypertension risk by strata defined by HTN-PRS in young adults from CARDIA. | Nature Communications

Fig. 6: Trajectories of hypertension risk by strata defined by HTN-PRS in young adults from CARDIA.

From: A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

Fig. 6: Trajectories of hypertension risk by strata defined by HTN-PRS in young adults from CARDIA.

Results from analysis of age-dependent risk of hypertension in young adults from CARDIA (stage 3 dataset). We used generalized linear mixed model to model the risk of hypertension by age within strata defined by quantiles of the HTN-PRS. Analyses were adjusted for age, sex and the first 11 PCs of genetic data. Stratification by PRS quantiles was performed in each presented group: All (combined Black and White participants), Black, and White. The effect of age was modeled using a second degree polynomial. At each point on the curve we provide 95% confidence interval of the effect estimate. In the combined sample, all individuals in the top PRS strata are Black, and 99 % of the individuals in the bottom PRS strata are White.

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